4th September 2020

Cambridge Consultants Unveil Flowfect™ Tx

Cambridge Consultants Unveil Flowfect™ Tx

Kytopen, an MIT spin-out company, and Cambridge Consultants, part of Capgemini, announce the initial release of the Flowfect™ Tx System, representing a leap forward in non-viral delivery of genetic material into cells. This breakthrough will speed the manufacture of cell therapies, an exciting category of living medicines where engineered cells tackle diseases. Kytopen will now make the Flowfect™ Tx System available to select bio-pharma partners and collaborators to accelerate their engineered cell therapy production.

Emerging cell therapies open up new and effective ways of treating disease, but difficulties in manufacturability, scalability and cost have slowed progress. Cambridge Consultants collaborates with visionary clients such as Kytopen to solve these issues, ultimately working to deliver the full promise of cell therapies to patients around the globe.

The Flowfect™ technology virtually eliminates these challenges, providing an effective, gentle process that produces billions of healthy, high-quality engineered cells in minutes. The Flowfect™ Tx System enables both process optimization and manufacturing at scale, faster and more efficiently than ever before.

The Flowfect™ Tx System features an automated, single use closed system for maximum ease of use and flexibility. This non-viral delivery technology uses continuous fluid flow combined with electric fields for high efficiency delivery of payloads such as mRNA, DNA, and CRISPR RNP complexes. The Flowfect™ technology is compatible with a variety of cells, including iPSCs, primary T cells, and other human hematopoietic cells being developed for immuno-oncology and gene editing applications. High-quality engineered cell products will ultimately translate into more effective and more accessible cell therapies for patients.

The Flowfect™ Tx System is part of a broader discovery, optimization, and manufacturing platform that also includes the Flowfect™ Array, a high throughput system that enables evaluation of hundreds of programmable configurations for identification and optimization of delivery parameters. The proprietary Flowfect™ technology delivers identical transfection parameters across platforms, enabling immediate translation from discovery to process development and manufacturing scale-up, with minimal technical risk.

Cambridge Consultants is renowned for breakthrough innovations with the potential to change the world – in this case widening access to new therapies with curative potential. The company brought its deep expertise in engineering, human factors, cell therapy manufacturing and rapid prototyping to the Flowfect™ Tx System design and build process. With a track record of working with ambitious start-ups to commercialize core technology, Cambridge Consultants is also forging a strong reputation in the fast-growing bioinnovation space, applying radical innovation across biology, process development and analytics.

These strengths were recognized by Kytopen when it engaged Cambridge Consultants in 2019 to help accelerate the engineering of its standalone Flowfect™ Tx System. Kytopen’s core technology was originally developed in Professor Cullen Buie’s laboratory at MIT before he and Kytopen CEO and Co-Founder Paulo Garcia were backed by ‘The Engine’. The “tough tech” ecosystem at The Engine and the world-class team at Kytopen have driven significant technological advances since spinning out of MIT in 2017. With an ambition to revolutionize cell engineering and widen patient access to next-generation treatments, Kytopen is working to enable efficient and cost-effective manufacture of cell therapies in days rather than weeks.

To learn more about the Flowfect™ Tx System please visit:


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